Multiwave Spectrophotometry for Therapy of Aging in the iUventa Project

Multiwave Spectrophotometry

Currently, a large number of aging biomarkers are known and for a comprehensive assessment of the state of the body, a large number of expensive tests are required. This greatly limits the massive study of the mechanisms of aging.
In addition, the lack of a holistic theory of aging makes it impossible to conduct a comprehensive assessment of the state of the body.

Spectrophotometry is a method of chemical analysis based on measuring the intensity of the absorption of light passing through a solution when irradiated with light of different wavelengths. This absorption depends on the composition of the solution and the concentration of the substances it contains.

Blood is a system that binds all organs and tissues; therefore, aging, being a process occurring in the hole the body, lead the changes in blood biochemical parameters. Changes in the biochemical composition of blood are reflected in changes in spectrometric parameters.

At present, multiwave spectrometric methods have found quite narrow application in medicine. In particular, for the evaluation of acute endotoxemia.

However, the applied methods for assessing the direction of change do not rely on the mathematical apparatus and do not single out clear criteria for diagnosing a condition.

We will conduct a series of studies of the spectrometric indicators of the absorption of whole blood diluted with saline, centrifuged hemolysate of blood and blood plasma of dogs and humans. Each sample will give 455 measurement points of the absorption indices (in the range of 190-1100 nm with a throughput of 2 nm).

The resulting data will be used as input data for training the deep neural network.